Liu Y, Liu M, Ren P
[Drug delivery of CPC/cisplatin complex in vitro and its ability to repair bone defect and eliminate tumor in vivo.] [English Abstract, Journal Article]
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2009 Oct; 34(10):991-7.
Objective To explore the best mass ratio of calcium phosphate cement (CPC)/cisplatin complex filling and to repair bone defect caused by tumor resection.Methods Mixed-molding method was used to obtain cisplatin/calcium phosphate cement complex at 0, 0.1%, 0.2%, and 0.4% mass ratio. Drug concentration was determined by atomic absorption spectrophotometry. Bone defect of rabbits and osteosarcoma of rats were prepared. We implanted CPC and CPC/cisplatin complex to observe the repair of bone defect and the inhibition of tumor in vivo.Results CPC containing 0.1%~0.2% cisplatin not only repaired the bone defect in rabbits but also eliminated osteosarcoma in rats. Conclusion CPC containing 0.1%~0.2% cisplatin can repair bone defect and eliminate tumor without influencing the prosthetic precess.
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